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Contraindicated (one)pentobarbital will lessen the extent or influence of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with sturdy CYP3A4 inducers can result in lessened serum concentrations and lack of antimalarial efficacy
pentobarbital will minimize the extent or influence of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Not known.
pentobarbital decreases outcomes of hemin by pharmacodynamic antagonism. Use Caution/Check. Medicine that raise delta-aminolevulinic acid synthetase may perhaps minimize hemin influence.
pentobarbital will lessen the extent or influence of rolapitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Extended-phrase coadministration of potent CYP3A4 inducers with rolapitant might significantly lessen rolapitant efficacy.
pentobarbital will lower the level or effect of isavuconazonium sulfate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Remark: Barbiturates may perhaps enhance adverse outcomes, like respiratory depression, made by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates maximize metabolism and decrease blood concentrations of TCAs.
pentobarbital will minimize the extent or influence of darunavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will decrease the level or outcome of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unidentified.
pentobarbital will minimize the extent or influence of methylprednisolone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will decrease the extent or outcome of paclitaxel protein sure by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Mysterious.
pentobarbital will lower the level or outcome of tipranavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will lessen the extent or influence of hydrocortisone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will decrease the level or influence of ibuprofen by influencing hepatic enzyme CYP2C9/ten metabolism. Insignificant/Significance Unfamiliar.
Phenytoin and barbiturate blood stages should be monitored far more routinely if provided concurrently; outcome of barbiturates on phenytoin metabolism more info described to become variable; sodium valproate and valproic acid look to lessen barbiturate metabolism; check barbiturate blood levels and make acceptable dosage changes as needed